Correlation between iron metabolism and coronary artery stenosis

Objective:To explore the correlation between iron metabolism and coronary artery stenosis in patients with coronary heart disease(CHD).Methods:Ninety-four CHD patients and 94 non-CHD patients were divided into the observation group and control group,respectively.The serum ferritin(SF) level and total iron binding capacity(TIBC) and ratio of SF/TIBC between two groups were compared.Results:The SF level and ratio of SF/TIBC in observation group were significantly higher than those in control group,and the TIBC in observation group was significantly lower than that in control group(P<0.01).The differences of the SF level,TIBC and ratio of SF/TIBC between mild stenosis group,moderate stenosis group and severe stenosis group were statistically significant(P<0.01).The results of pairwise comparison showed that the SF level and ratio of SF/TIBC in severe stenosis group were higher than those in mild stenosis group and moderate stenosis group,the TIBC in severe stenosis group was lower than that in other two groups(P<0.05 and P<0.01).The ratio of SF/TIBC in moderate stenosis group was higher than that in mild stenosis group,and the TIBC in moderate stenosis group was significantly lower than that in mild stenosis group(P<0.01).The Gensini score in CHD patients was significantly positive correlated with SF level and ratio of SF/TIBC(r=0.419,r=0.624,P<0.05),and significantly negatively correlated with TIBC(r=-0.347,P<0.05).Conclusions:Iron overload is closely associated with coronary artery stenosis in CHD patients.The iron metabolism indexes should be regularly detected in CHD patients.