Relationship between the serum levels of cTnI,Lac,CK-MB,LDH,CRP, NSE,and carbon monoxide poisoning delayed encephalopathy

Objective:To investigate the relationships between the serum levels of troponin I(cTnI),lactic acid(Lac),creatine kinase(CK),creatine kinase isoenzyme(CK-MB),lactate dehydrogenase(LDH),C reactive protein(CRP),neuron-specific enolase(NSE) and mean apparent diffusion coefficient(ADC),and carbon monoxide poisoning delayed encephalopathy(DEACMP).Methods:The clinical data of 56 patients with acute carbon monoxide poisoning(ACMP) were retrospectively analyzed.The age,sex,and degree of coma of patients were collected,and the levels of COHb,Lac,cTnI,CK,CK-MB,LDH,NSE,WBC count and CRP within 24 hours of onset,and the mean ADC value of bilateral globus pallidus,around ventricle and center of semi-soft circle in MRI imaging were observed within 48 hours of admission.According to the DEACMP after 60 days,the patients were divided into onset or not of DEACMP group and non-DEACMP group.The levels of COHb,Lac,cTnI,CK,CK-MB,LDH,NSE,WBC count and CRP,and the mean ADC value of bilateral globus pallidus,around ventricle and center of semi-soft circle between two groups were compared and analyzed using logistic regression analysis method.Results:The incidence rate of coma in DEACMP group(15 cases,75.00%) was significantly higher than that in non-DEACMP group(12 cases,33.33%)(P<0.01).The levels of Lac,CK,CK-MB,LDH,CRP and NSE in DEACMP group were higher than those in non-DEACMP group(P<0.05 to P<0.01),while there was no significant difference n the levels of COHb,cTnI and WBC count between two groups(P>0.05).The ADC value of globus pallidus region in DEACMP group was significantly higher than that in non-DEACMP group(P<0.01),while there was no significant difference in the ADC values of the white matter around the lateral ventricle and central region of semi-soft circle between two groups(P>0.05).The results of logistic regression analysis showed that the coma degree,poisoning time,and levels of NSE,CK,CRP and LDH might be the independent risk factors of DEACMP,and the difference of which was statistically significant(P<0.05 to P<0.01).Conclusions:The serum levels of Lac,CK,CK-MB,LDH,CRP and NSE maybe related to the DEACMP,which has important significance in the diagnosis and prognosis of DEACMP.