Effect of the modified Yangmo decoction combined with estrogen on endometrial receptivity and uterine hemodynamics in patients with kidney deficiency and blood stasis type thin endometrium

Objective:To investigate the effects of the modified Yangmo decoction combined with estrogen on the endometrial receptivity and uterine hemodynamics in patients with kidney deficiency and blood stasis type thin endometrium.Methods:Seventy patients with kidney deficiency and blood stasis type thin endometrium were randomly divided into the combined group and control group(35 cases each group).The control group were treated with estrogen supplement,and the combined group were additionally treated with the modified Yangmo decoction based on the control group.The levels of sex hormone and endometrial vascular endothelial growth factor,uterine hemodynamics,endometrial thickness and shape,pregnancy outcome,and adverse reactions between two groups were compared.Results:After 3 months of treatment,the differences of the levels of estradiol and endometrial vascular endothelial growth factor,uterine spiral artery resistance index and endometrial thickness between two groups were statistically significant(P<0.01).The ratios of type A and type B endometrium,and ratio of type C in combined group increased and decreased after treatment,respectively(P<0.01).Conclusions:The modified Yangmo decoction combined with estrogen can improve the endometrial blood supply,promote endometrial growth and improve endometrial receptivity.