Comparison of curative effect of different doses of poractant alfa injection in the treatment of neonatal respiratory distress syndrome

Objective:To observe the effects of the different first doses of poractant alfa injection in the treatment of neonatal respiratory distress syndrome(NRDS) in premature infants.Methods:Eighty-one premature infants(gestational age < 37 weeks) with NRDS were divided into the high dose group(29 cases),medium dose group(25 cases) and low dose group(27 cases),and treated with 200,150 and 100 mg/kg poractant alfa injection combined with appropriate symptomatic support treatment,respectively.Results:The significant improvement of chest film,and levels of PaO₂ and PaCO₂ in high dose group was significantly higher that in medium and low dose groups(P<0.01),and the average mechanical ventilation time and oxygen cure time in high dose group were lower than those in medium and low dose groups(P<0.05 to P<0.01).The differences of the total incidence rates of patent ductus arteriosus,severe infection,intracranial hemorrhage,death and giving up treatment between three groups were statistically significant(P<0.01),and which in high dose group,medium dose group and low dose group gradually decreased in turn.Conclusions:The 200 mg/kg poractant alfa injection in the treatment of NRDS in premature infants can significantly improve the chest film and arterial blood gas analysis,shorten the mechanical ventilation time and oxygen therapy time,and is worthy of promotion in clinic.