Application effect of the oxycodone combined with etomidate in painless artificial abortion

Objective:To explore the effects of different doses of oxycodone combined with etomidate in the application of painless artificial abortion.Methods:One hundred and twenty early pregnancy patients scheduled by painless artificial abortion were randomly divided into the fentanyl group,low,medium and high dose of oxycodone groups(30 cases each group).The fentanyl group,low,medium and high dose of oxycodone groups were treated with 1.0 μg/kg fentanyl,and 0.05,0.1 and 0.15 mg/kg oxycodone by intravenous injection,respectively.All cases were treated with 0.3 mg/kg etomidate by intravenous injection after 5 min,and operated after the disappearance of eyelash reflex.The efficacy and safety between four groups were compared.Results:The differences of the time of eyelash reflex disappearing,open the eyes after calling and wide-awake between four groups were not statistically significant(P>0.05).The number of the cases treated with additional etomidate in fentanyl group,medium and high dose of oxycodone groups were significantly less than that in low dose of oxycodone group(P<0.01).During etomidate treatment to wide-awake,the differences of blood pressure,heart rate,respiration rate and pulse oxygen saturation between four groups were not statistically significant(P>0.05).The scores of uterine contraction pain in medium and high dose of oxycodone groups at wide-awake and after 30 min and 2 h of awake were significantly lower than that in low dose of oxycodone group(P<0.01),and the scores of uterine contraction pain in high dose of oxycodone group at wide-awake,and in medium and high dose of oxycodone groups after 30 min and 2 h of awake were significantly lower than that in fentanyl group(P<0.05 to P<0.01).The differences of the number of the cases with dizziness,respiratory depression,nausea and vomiting between four groups were not statistically significant(P>0.05),and the number of the cases with myoclonus in medium and high dose of oxycodone groups were significantly less than that in fentanyl group and low dose of oxycodone group(P<0.05 to P<0.01).Conclusions:The effect of 0.1 mg/kg oxycodone combined with etomidate in the application of painless artificial abortion is better,which can reduce the uterine contraction pain and myoclonus.