The value of the platelet parameters in evaluating the disease activity of ankylosing spondylitis

Objective:To explore the value of the platelet count(PLT) and mean platelet volume(MPV) in evaluating the disease activity of ankylosing spondylitis(AS).Methods:The levels of PLT,MPV,scores of Bath ankylosing spondylitis disease activity index(BASDAI),erythrocyte sedimentation rate(ESR),C reactive protein(CRP),immunoglobulin(IgG) and hemoglobin(Hb) in 71 patients with AS were compared and analyzed.Results:Compared with the stable AS patients and control group,the PLT in active AS patients increased(P<0.01).Compared with the patients with normal PLT,the levels of ESR,CRP and IgG increased in patients with PLT increasing(P<0.01),but the levels of Hb and MPV decreased in patients with PLT increasing(P<0.05 and P<0.01).The level of PLT in AS patients was positively correlated with the levels of ESR,CRP and IgG(P<0.05 to P<0.01),and negatively correlated with the levels of Hb and MPV(P<0.01).Conclusions:The changes of PLT and MPV are associated with the disease activity of AS,which can be used as one of disease activity indicators in reflecting AS.