Application value of thrombelastogram in antiplatelet therapy in patients with cardia-cerebrovascular disease

Objective:To analyze the results of thrombelastography(TEG) in cardia-cerebrovascular disease patients treated with antiplatelet,and provide the reference for clinical therapy.Methods:Two hundred and forty-nine cardia-cerebrovascular disease patients were divided into the aspirin group(group AA,141cases),clopidogrel group(group ADP,20 cases) and aspirin and clopidogrel combination group(combination group,88 cases) according to the use of antiplatelet agent.The platelet inhibition rates in three groups were detected by thromboelastography,and the differences of the efficacy of antiplatelet treatment between three groups were compared.Results:The platelet inhibition rates in combination group induced by AA and ADP receptor pathway were (88.47±19.69)% and (68.08±28.12)%,respectively,which was higher than that in group AA(77.71±29.7)% and in group ADP(52.57±26.97)%(P<0.01 and P<0.05).The incidence rates of aspirin and clopidogrel resistance in combination group were 6.82% and 11.36%,respectively,which was lower than that in group AA(21.99%) and group ADP(30%)(P<0.01 and P>0.05).Conclusions:The inhibition rate of platelet aggregation detected by using TEG is helpful to formulate individualized antiplatelet therapy in cardia-cerebrovascular disease patients.The effect of aspirin on the inhibition of platelet aggregation in cardia-cerebrovascular disease patients is higher than that of clopidogrel.Antiplatelet resistance is found in patients treated with standard dose of antiplatelet therapy.There is a synergistic effect in the combination use of asprin and clopidogrel in antiplatelet therapy.