The relationship between the levels of HDGF,VEGF and MVD in hepatocellular carcinoma,and its effect on the prognosis of patients

Objective: To investigate the expression levels of hepatoma-derived growth factor(HDGF) and vascular endothelial growth factor(VEGF) in hepatoma tissue,and its correlations with microvessel density(MVD) and prognosis of patients.Methods: The expression levels of HDGF,VEGF and MVD in 94 liver pathology specimens and para-carcinoma tissue of more than 2 cm distance from tumor lesions were investigated using immunohistochemstry.Results: The positive expression rates of HDGF protein and VEGF protein(62.77%,65.96%) in hepatocellular carcinoma tissue were higher than those in para-carcinoma tissue(15.96%,19.15%)(P<0.01),and the MVD in hepatocellular carcinoma tissue was higher than that in para-carcinoma tissue(P<0.01).The expression levels of HDGF and VEGF in hepatocellular carcinoma tissue were positively correlated with the MVD count(P<0.01).The 3-year survival rate in patients with positive HDGF expression(19.61%) was lower than that in patients with negative HDGF expression(47.06%)(P<0.01).The 3-year survival rate in patients with positive VEGF expression(14.81%) was lower than that in patients with negative VEGF expression(56.25%)(P<0.01).Conclusions: The expression levels of HDGF and HDGF in hepatocellular carcinoma tissue increase,and which is positively correlated with MVD.The positive expressions of HDGF and HDGF are harmful to the long-term prognosis of patients.