Correlation analysis of the serum level of 25-hydroxy vitamin D₃ with inflammation and nutritional status in maintenance hemodialysis patients

Objective: To analyze the correlations of the indexes of nutrition and inflammation with serum levels of 25-hydroxy D₃ in maintenance hemodialysis(MHD) patients so as to supply the basis for clinical nutrition evaluation.Methods: The serum level of 25-hydroxy vitamin D₃,and indexes of clinical nutrition and inflammation in 127 patients treated with MHD were detected.The correlations of the serum levels of 25-hydroxy vitamin D₃ with indexes of nutrition and inflammation with in all patients were analyzed by the results of malnutrition-inflammation score(MIS).Results: All patients were divided into the normal serum vitamin D₃ group(19 cases),insufficient vitamin D₃ group(90 cases) and deficient vitamin D₃group(18 cases).The results of ANOVA analysis indicated that the differences of the levels of TP,ALB,HCY,CRP and TC between three groups were statistically significant(P<0.05).The correlation analysis indicated that the level of vitamin D₃ was positively correlated with the levels of TP,HB,ALB and serum calcium(P<0.05),and negatively correlated with the level of CRP(P<0.01).The results of multi-factorial linear regression analysis showed that the ALB and CRP were main influencing factor of vitamin D₃.Conclusions: The incidence of 25-hydroxy vitamin D₃ insufficiency or deficiency is high in MHD patients.The inflammation status and nutritional condition are closely correlated with the serum level of 25-hydroxy vitamin D₃.