Effect of Yishen Huoxue Tongluo Yin in the treatment of diabetic nephropathy

Objective: To investigate the clinical effects of Effect of Yishen Huoxue Tongluo Yin in the treatment of diabetic nephropathy.Methods: Eighty-four patients with diabetic nephropathy were randomly divided into the control group and observation group(42 cases each group).The control group and observation group were treated with valsartan capsule and Yishen Huoxue Tongluo Yin,respectively.The clinical effects and related indexes between two groups were compared.Results: The total effective rate in observation group(88.09%) was higher than that in control group(73.81%)(P<0.05).Before treatment,the differences of the levels of urinary albumin,24 h urinary albumin,urea nitrogen,serum creatinine and glomerular filtration rate between two groups were not statistically significant(P>0.05).After treatment,all indexes in observation group were significantly improved(P<0.01),and which in observation group was significantly better than that in control group(P<0.01).Before treatment,the differences of the levels of MCP-1,hs-CRP and TNF-α between two groups were not statistically significant(P>0.05).After treatment,the levels of MCP-1,hs-CRP and TNF-α in observation group significantly decreased compared with before treatment(P<0.01),the differences of the levels of MCP-1,hs-CRP and TNF-α in control group between before and after treatment were not statistically significant(P>0.05),and the levels of MCP-1,hs-CRP and TNF-α in observation group were lower than those in control group(P<0.05 to P<0.01).Conclusions: The treatment effect of diabetic nephropathy with Yishen Huoxue Tongluo Yin is good.