Effect of the different tidal volume of mechanical ventilation on postoperative old patients with lung cancer

Objective:To explore the effects of the different tidal volume of mechanical ventilation on postoperative old patients with lung cancer.Methods:One hundred postoperative elderly patients with lung cancer were divided into the 6 mL/kg group(group A),8 mL/kg group(group B) and 10 mL/kg(group C) according to the tidal volume of mechanical ventilation.The postoperative blood gas analysis indicators,related inflammatory factors,respiratory indexes and complications between three groups were compared.Results:At timepoint T₁,T₂ and T₃,the levels of P_ETCO₂ in group B and C were lower than that in group A(P<0.05),which in group C was significantly lower than that in group B(P<0.01).The peak airway pressure level in group C was significantly higher than that in group A and B(P<0.01).The differences of the levels of P_ETCO₂ between timepoint T₁,T₂ and T₃ in group A and B were not statistically significant(P>0.05).The differences of the levels of P_ETCO₂ between timepoint T₁,T₂ and T₃ in group C were statistically significant(P<0.01),and which at T₂ and T₃ was significantly lower than that at timepoint T₁(P<0.01).The differences of the levels of peak airway pressure between three groups at timepoint T₁,T₂ and T₃ were statistically significant(P<0.01),which at timepoint T₃ in group A and B were higher than that at timepoint T₁ and T₂(P<0.01),and which at timepoint T₂ and T₃ in group C were significantly higher than that at timepoint T₁(P<0.01).There were statistical significances in the level of IL-1β between three groups at timepoint T₂(P<0.01),which in group B and C was lower than that in group A(P<0.05).There were statistical significances in the level of IL-6 between three groups at timepoint T₂ and T₃(P<0.01),which in group B at timepoint T₂ and T₃ were lower than that in group A(P<0.05),and which in group C at timepoint T₃ was higher than that in group A(P<0.05).There were statistical significances in lung compliance indicators between three groups at timepoint T₁,T₂ and T₃(P<0.01),which in group B and C were lower than that in group A(P<0.01),and which in group C at timepoint T₂ and T₃ were significantly higher than that in group B(P<0.01).There were statistical significances in overall complications between three groups(P<0.05),and which in group B significantly decreased(P<0.05).Conclusions:The effects of 8 mL/kg tidal volume of mechanical ventilation on the postoperative blood gas index,inflammatory factors and complications in elderly patients with lung cancer is little,which does not affect the lung ventilation function,and is a reasonable tidal volume of mechanical ventilation.