Change of hemorheology and coagulation fibrinolysis function in AECOPD patients complicated with diabetes mellitus

Objective:To explore the changes of hemorheology and coagulation fibrinolysis function in acute episode chronic occlusive pulmonary disease(AECOPD) patients complicated with diabetes mellitus.Methods:Fifty-two AECOPD patients complicated with diabetes mellitus,50 AECOPD patients and 40 healthy people were divided into the observation group,control group and normal group,respectively.The hemorheology indexes,four routine coagulation indexes,antithrombin-Ⅲ(AT-Ⅲ),D dimer(D-D) and fibrinogen degradation products(FDP) in three groups were detected.Results:The levels of whole blood viscosity,plasm viscosity,hematocrit and erythrocyte sedimentation rate in control group and observation group were significantly higher than those in normal group(P<0.01).The hemorheology indexes in observation group were significantly higher than that in control group(P<0.01).The coagulase coagulation time,prothrombin time and partial thrombin time in control group and observation group were significantly less than those in normal group(P<0.01),and the levels of fibrinogen,D-D and FDP in observation group were significantly higher than those in control group(P<0.01),and the coagulase coagulation time in observation group was significantly less than that in normal group(P<0.05).Conclusions:The hemorheology,and coagulation fibrinolysis function in AECOPD patients complicated with diabetes mellitus are obviously abnormal.