Clinical value of the detection of CA153 and CEA combined with fine needle aspiration cytology in the diagnosis of breast cancer

Objective:To investigate the value of the detection of serum carbohydrate antigen(CA) 153 and carcinoembryonic antigen(CEA) combined with fine needle aspiration cytology(FNAC) in the diagnosis of breast cancer.Methods:The serum levels of CA153,CEA,and FNAC in 67 patients with breast cancer and 32 patients with benign breast disease were detected.The values of the combined detection of CA 153,CEA and FNAC in the diagnosis of breast cancer were analyzed.Results:The sensitivity,specificity and accuracy of CA153 examination were 8.96%,100.00% and 38.38%,respectively.The sensitivity,specificity and accuracy of CEA examination was 16.42%,96.88% and 43.43%,respectively.The sensitivity,specificity and accuracy of FNAC examination were 83.58%,100.00%and 88.89%,respectively.The sensitivity,specificity and accuracy of three combined inspection were 88.06%,90.91% and 96.88%,respectively.The AUC values of CA 153,CEA and FNAC in the diagnosis of breast cancer were 0.910,0.709 and 0.705,respectively,and the AUC value of combined detection(0.942) was significantly higher than that of any signal marker.Conclusions:The combined detection of CA153,CEA and FNAC can improve the sensitivity and accuracy in the diagnosis of breast cancer,which has a high reference value in the early diagnosis of breast cancer.