Effect of dexmedetomidine on the emergence agitation in patients treated with laparoscopic cholecystectomy

Objective:To observe the effects of dexmedetomidine on the emergence agitation(EA) in patients treated with laparoscopic cholecystectomy.Methods:Sixty patients with ASAⅠ~Ⅱ laparoscopic cholecystectomy were randomly divided into the dexmedetomidine group and remifentanil group using double blind method(30 cases each group).Two groups were treated with tracheal intubation inhalation and intravenous injection combined with general anesthesia.The dexmedetomidine group was injected intravenously with 1.0 ug/kg of dexmedetomidine before ten minutes of induction,the 1ug/kg of remifentanil,2 mg/kg of propofol and 0.6 mg/kg of rocuronium were intravenously injected,0.2~0.5 μg·kg^-1·h^-1 of dexmedetomidine,3 mg·kg^-1·h^-1 of propofol,0.2 μg·kg^-1·min^-1 of remifentanil and 1%~2% of sevoflurane were continuously inhaled,and 0.15 mg/kg of rocuronium bromide was intermittently intravenously injected in turn in dexmedetomidine group.Except the dexmedetomidine in remifentanil group,the other drugs were used in consistent with the dexmedetomidine group.The recovery time and EA scores before extubation,at extubation and after 10 min of extubation between two groups were compared.Results:There was no statistical significance in the operation time,spontaneous breathing recovery time and eye opening time between two groups(P>0.05).The SBP in dexmedetomidine group at different time-points were lower than that in remifentanil group(P<0.05 to P<0.01).The difference of HR at T1 between two groups was not statistically significant(P>0.05),and the differences of HR in dexmedetomidine group at T2 and T3 were significantly lower than that in remifentanil group(P<0.01).The EA scores in dexmedetomidine group before extubation,at extubation and after 10 min of extubation were significantly lower than that in remifentanil group(P<0.01).Conclusions:Dexmedetomidine can maintain the stabilization of hemodynamics,and reduce the incidence of EA in patients treated with laparoscopic cholecystectomy.