Study on the correlation between T-lymphocyte subgroup count of peripheral blood and malignant tumor

Objective: To investigate the clinical significance of T-lymphocyte subgroup count of peripheral blood in malignant tumor.Methods: The amount of CD3⁺ cells,CD4⁺ cells,CD8⁺ cells and ratio of CD4⁺/CD8⁺ of peripheral blood in 80 malignant tumor patients and 100 healthy people were determined by flow cytometry.Results: Compared with healthy people,the amount of CD3⁺ cells,CD4⁺ cells,CD8⁺ cells and ratio of CD4⁺/CD8⁺ in patients with malignant tumor were significantly decreased(P<0.01).The results of subgroup analysis showed that the counts of CD3⁺ cells and CD4⁺ cells in malignant tumor patients decreased compared with control group(P<0.05 to P<0.01),the difference of the count of CD8⁺ cells between two groups was not statistically significant(P>0.05),and ratio of CD4⁺/CD8⁺ in lung cancer group was lower than that in control group(P<0.05).The difference of the parameter of malignant tumor patients between the first diagnosis group and progression group was not statistically significant(P>0.05).The amount of CD4⁺ cells in amale patients was lower than that in female patients(P<0.05).Conclusions: The imbalance of the counts of CD3⁺ cells,CD4⁺ cells,CD8⁺ cells and ratio of CD4⁺/CD8⁺ in malignant tumor patients are identified,which can be used to evaluate the immunity status of tumor patients,and provide a scientific evidence in immunotherapy of tumor.