Effect of propofol anesthesia on the levels of Cor and blood glucose in female patients treated with minimally invasive surgery

Objective:To analyze the effects of propofol anesthesia on the levels of cortisol(Cor) and blood glucose in female patients treated with minimally invasive surgery.Methods:Sixty patients treated with laparoscopic myomectomy were divided into the sevoflurane group(n=30) and propofol group(n=30) according to the random number table method.After anesthesia induction,the sevoflurane was inhaled in sevoflurane group,and the propofol was infused in propofol group.The levels of mean arterial pressure(MAP),heart rate(HR),cortisol(Cor),blood glucose,insulin,C peptide,glucagon(Glu) between two groups were compared at the establishment of pneumoperitoneum(T₁) and after 10 min and 30 min of pneumoperitoneum(T₂ and T₃) and during surgery(T₄).Results:The differences of the anesthesia time,opening eye time,operation time and awaking time between two groups were not statistically significant(P>0.05).The differences of the anesthesia time,opening eye time,operation time and awaking time between two groups were not statistically significant(P>0.05).The differences of the amount of colloidal fluid,total fluid infusion volume,number of vasoactive drug use and amount of opioid use between two groups were not statistically significant(P>0.05).The differences of the levels of MAP and HR between two groups at different time-points were not statistically significant(P>0.05).The levels of Cor,blood glucose,insulin,C peptide and Glu in two groups at T₂,T₃ and T₄ were higher than those at T₁(P<0.05 to P<0.01).At T₁,the differences of the levels of Cor,blood glucose,insulin,C peptide and Glu between two groups were not statistically significant(P>0.05).At T₂,the levels of blood glucose and Glu in propofol group were lower than those in sevoflurane group,and the level of C peptide in propofol group was higher than that in sevoflurane group(P<0.05).At T₃ and T₄,the levels of Cor,blood glucose and Glu in propofol group were lower than those in sevoflurane group,and the levels of insulin and C peptide in propofol group were higher than that in sevoflurane group(P<0.05 to P<0.01).Conclusions:Propofol and sevoflurane can effectively maintain the stabilization of hemodynamics in patients treated with laparoscopic myomectomy.The propofol can promote the secretion of C peptide and insulin,and inhibit the excessive secretion of Glu,Cor and hyperglycemia during operation.Compared with sevoflurane,the effect of propofol on reducing the intraoperative stress response is better.