The association between cognitive function and the serum levels of interleukin-6, interleukin-8 and homocystine in past-stroke depression patients

Objective:To investigate the relationships between the levels of interleukin(IL)-6,IL-8,homocystine(Hcy) and cognitive function in patients with post-stroke depression.Methods:The cognitive abilities of 200 patients with post-stroke depression were detected using the mini-mental state examination(MMSE).The logic ST model was established by the backward iteration method for screening common susceptible factors.The correlations between the levels of IL-6,IL-8 and Hcy,and cognitive function were analyzed.Results:The gender,age,blood loss,depression time,intraoperative anesthetic dosage,intraoperative bleeding,operation time,discharge time,mental disease,bad living habit,and levels of IL-6,IL-8 and Hcy were associated with the cognitive function declining.The weighting coefficients of Hcy,IL-6 and IL-8 were higher(2.485,2.547 and 2.641,respectively).Conclusions:The levels of IL-6,IL-8 and Hcy in patients with post-stroke depression maybe play a certain role in cognitive declining.