Effect of different protein diets on the nutritional status and bone mineral metabolism in maintenance hemodialysis patients

Objective: To investigate the effects of different protein intake on the nutritional status and bone mineral metabolism in maintenance hemodialysis(MHD) patients.Methods: Eighty-four MHD patients were divided into the high intake group(n=42) and low intake group(n=42) according to different protein intakes.The protein intakes in the high intake group and low intake group were(1.32±0.15) g·kg^-1·d^-1 and(1.02±0.08) g·kg^-1·d^-1,respectively.The nutritional status and bone mineral metabolism in two groups were observed.Results: There was no statistical significance in body mass,body mass index,waist-hip ratio,upper arm muscle circumference,serum albumin,prealbumin and hemoglobin between two groups(P>0.05).The creatinine,urea nitrogen,total cholesterol,and normalized nitrogen performance equivalent protein in high intake group were higher than those in low intake group(P<0.05 to P<0.01).The levels of serum potassium,calcium,phosphorus and iPTH in high intake group were significantly higher than those in low intake group(P<0.01),and the level of carbon dioxide combining power in high intake group was significantly lower than that in low intake group(P<0.01).There was no statistical significance in the number of patients with residual renal function,urine volume and glomerular filtration rate between two groups(P>0.05),but the loss time in low intake group with residual renal function was significantly longer than that in high intake group(P<0.01).Conclusions: Controlling daily protein intake at about 1.02 g/kg in MHD patients can help to patients maintain a good nutritional status,and residual renal function for a long time.