Effect of hyperbaric oxygen on immune function and prognosis in the early comprehensive treatment of patients with craniocerebral injury

Objective: To explore the effects of hyperbaric oxygen(HBO) on immune function and prognosis in the early comprehensive treatment of patients with craniocerebral injury.Methods: One hundred and eighteen patients with craniocerebral injury were randomly divided into the control group(59 cases) and observation group(59 cases).The control group were treated with HBO after 31 to 60d of craniocerebral injury,and the observation group were treated with HBO after 8 to 30d of craniocerebral injury.The scores of GCS and ADL,level of inflammatory cytokine,immune indicator,GOS staging and complications between two groups were compared.Results: After three courses of treatment,the scores of GCS and ADL in observation groups were significantly higher than those in control group(P<0.01).After two weeks of treatment,the levels of IL-2,IL-6,IL-8 and TNF-α in observation group were significantly lower than those in control group(P<0.01),and the levels of IgG,IgA,IgM and TLC in observation group were significantly higher than those in control group(P<0.01).The GOS staging in observation group was significantly better than that in control group(P<0.01).The incidence rate of complication in observation group was significantly lower than that in control group(P<0.01).Conclusions: The effect of HBO in the early comprehensive treatment of patients with craniocerebral injury is significant,which can significantly reduce the level of inflammatory cytokine and incidence of complication,improve the patients' immune function,and is safe and worthy of promotion in clinic.