Analysis of the clinical features and etiology in 124 neonatal septicemia cases

Objective: To analyze the clinical and etiologic features of neonatal septicemia.Methods: The clinical data of 124 neonatal septicemia cases from March 2013 to February 2017 were retrospectively analyzed.The patients were divided into the early onset group and late onset group according to the onset time,and the difference between two groups was compared.Results: The ratio of neonatal septicemia cases to the hospitalized newborns at the same time was 3.4%(124/3634),54.8% of which was the early onset type,and the major performances of which were jaundice,groans,cyanosis,dyspnea,responsiveness decreasing and C-reactive protein increasing.The 45.2% of patients were the late onset type,and the major performances of which were fever,dyspnea,jaundice,and focal infection.The incidence rates of the premature rupture of fetal membrane and amniotic fluid pollution in early onset group were higher than those in late onset group(P<0.05),the incidence rates of jaundice,groan,cyanosis,dyspnea and poor response in early onset group were significantly higher than those in late onset group(P<0.01).The incidence rate of the pneumonia complicated with focal infection in early onset group was lower than that in late onset group(P<0.01 and P<0.05).Among the septicaemic pathogens,88.7% of which was gram-positive bacteria,and 11.3% of which was gram-negative bacteria.The gram-positive bacteria was highly sensitive to vancomycin,minocycline and fusidic acid,and the gram-negative bacteria was highly sensitive to carbapenems.Conclusions: The clinical features between early onset and late onset neonatal septicemia are different,and the early onset disease is severe.The staphylococcus and escherichia coli are the main pathogens of septicemia.The clinical features and main pathogens of septicemia are the reference in antibiotics use,and the adjustment of antibiotics should accord to the bacterial culture result and drug sensitivity.