Effect of periodontal basic treatment on the PLI,PD, and expression levels of hs-CRP in serum and gingival crevicular fluid

Objective: To investigate the effects of periodontal basic treatment on plaque index(PLI),periodontal probing depth(PD) and expression levels of high sensitivity C reactive protein(hs-CRP) in serum and gingival crevicular fluid in patients with periodontitis.Methods: Sixty-four patients with chronic periodontitis and 64 healthy volunteers were divided into the case group and control group,respectively.The case group was treated with periodontal basic treatment.The PLI,PD,attachment loss(AL) and levels of hs-CRP,interleukin-6(IL-6),interleukin-8(IL-8) in serum and gingival crevicular fluid were observed in two groups.Results: Before and after treatment,the PD,PLI and AL in case group were significantly higher than those in control group(P<0.01).The PD,PLI and AL in case group after treatment significantly decreased compared with before treatment(P<0.01).Before and after treatment,the levels of IL-6,IL-8 and hs-CRP in serum and gingival crevicular fluid in case group were significantly higher than those in control group(P<0.01).The levels of IL-6,IL-8 and hs-CRP in serum and gingival crevicular fluid in case group after treatment significantly decreased compared with before treatment(P<0.01).The PD was positively correlated with the levels of IL-6,IL-8 and hs-CRP in serum and gingival crevicular fluid(P<0.05),and the AL was positively correlated with the levels of IL-6,IL-8 and hs-CRP in serum and gingival crevicular fluid(P<0.05).Conclusions: Periodontal basic treatment can effectively improve the periodontal and inflammatory status in patients with periodontitis.