The short-term clinical efficacy and safety of paclitaxel combined with cisplatin byhyperthermic intraperitoneal perfusion in the treatment of gastric cancer complicated with ascites

Objective:To investigate the clinical efficacy and safety of paclitaxel combined with hyperthermic intraperitoneal infusion of cisplatin in the treatment of gastric cancer patients with ascites.Methods:Seventy-five gastric cancer patients with ascites were divided into the observation group and control group according to the different treatment methods.The observation group was treated with intravenous infusion of paclitaxel combined with hyperthermic intraperitoneal perfusion circulation cisplatin,and the control group was treated with intravenous infusion of paclitaxel combined with direct abdominal infusion of cisplatin.The clinical effects,level of serum carcinoembryonic antigen(CEA),quality of life,1-year cumulative survival rate and incidence rate of adverse reaction between two groups were compared.Results:The total effective rates of observation group and control group were 60.00% and 37.14%,respectively,and the difference of which was statistically significant(P<0.05).The decreasing degree of serum CEA level in observation group was more significant compared with control group(P<0.01).The survival quality in observation group was better than that in control group after treatment(P<0.05).The degree of adverse reactions(nausea and vomiting) in observation group was lighter than that in control group(P<0.01),and the difference of other adverse reactions between two groups was not statistically significant(P>0.05).The difference of 1-year cumulative survival rate between two groups was not statistically significant(P>0.05).Conclusions:The short-term clinical efficacy of paclitaxel combined with hyperthermic intraperitoneal infusion of cisplatin in the treatment of gastric cancer patients with ascites is good,which can improve the survival quality of patients,and prolong the survival time of part of patients.The adverse reaction can be tolerated by patients.