Study on the relationship between the distant pain and thoracolumbar compression fractures

Objective:To study the relationship between the distant pain and thoracolumbar compression fractures.Methods:Sixty-five patients with thoracolumbar compression fractures were divided into observation group(13 cases) and control group(52 cases) according to the distant pain.The multifidus muscle tissue near the operation incision were detected using immunohistochemistry to identified the correlation of neurotransmitter with septal part pain.The compression degree of injury vertebra was calculated by the ratio of the height of vertebral anterior to posterior margin.The VAS score,ODI index and JOA between two groups before and after operation were compared.Results:There was no statistical significance in the compression degree of injury vertebral between two groups before and after operation(P>0.05),the compression degree of injured vertebra in two groups after operation was significantly improved compared with before operation(P<0.01).Before operation,the differences of the VAS and JOA score scores between two groups were not statistically significant(P>0.05),and the ODI index in observation group was significantly higher than that in control group(P<0.05).After operation,the score of VAS and ODI index in observation group was significantly higher than that in control group(P<0.01),and the score of JOA in observation group was significantly lower than that in control group(P<0.01).The results of immunohistochemistry showed that the antibodies of SP,CGRP and IL-6 were positive,the brown granules in cytoplasm of vascular endothelial cell and tissue adjacent to blood vessels were found in observation group.The antibodies of SP,CGRP and IL-6 in control group were negative.Conclusions:The SP,CGRP and IL-6 neurotransmitter-mediated inflammatory response may be a stimulus to the posterior ramus of spinal nerve,which may be the key cause of pain in distal part of thoracolumbar compression fractures.