Clinical application of serum bone metabolic markers in multiple myeloma

Objective:To investigate the levels of serum β-C-terminal telopeptide of typeⅠ collagen(β-CTX) and procollagenⅠN-terminal peptide(PINP) in patients with multiple myeloma(MM),and its clinical significance.Methods:The serum levels of β-CTX and PINP in 62 MM patients(MM group) and 50 healthy people(control group) were detected using the electrochemiluminescence immunoassay.The serum levels of β-CTX and PINP in different clinical stages patients with MM were compared between two groups.Results:The serum levels of PINP and β-CTX in MM groups were lower and higher than those in control group,respectively(P<0.01).The level of β-CTX in MM patients in stage Ⅲ was higher than that in stage Ⅰ (P<0.05),there was no statistical significance in the serum level of β-CTX between stage Ⅱ and stage Ⅰ or stage Ⅲ(P>0.05),and there was no statistical significance in the serum level of PINP among stage Ⅱ,stage Ⅰ and stage Ⅲ(P>0.05).Conclusions:The serum levels of PINP and β-CTX can be used to evaluate the degree of bone destruction in patients with MM.The level of β-CTX in evaluating the prognosis of patients with MM more sensitive than that of PINP.