Clinical study of the recombinant human epidermal growth factor promoting skin dilation by nanometer crystalliter

Objective:To study the clinical effects of the recombinant human epidermal growth factor(rhEGF) promoting skin dilation by nanometer crystalliter.Methods:A total of 30 patients treated with the two same capacity dilators were divided into the observation group and control group(30 dilators each group).The control group was treated with skin soft tissue dilator,and the observation group was treated with skin soft tissue dilator combined with the rhEGF transducted with nanometer crystalliter.The dilation time,skin expansion rate and skin immediate retraction rate in two groups were recorded,the skin thickness and quality in two groups were observed using HE staining,and the levels of hydroxyproline(OHP) and type Ⅰ,type Ⅲ collagen in wound were compared between two groups.Results:The dilation time and skin immediate retraction rate in observation group were significantly lower than those in control group(P<0.01).The skin expansion rate in observation group was significantly higher than that in control group(P<0.01).The hydroxyproline content in observation group was significantly higher than that in control group(P<0.01).The ratio of type Ⅰ to type Ⅲ collagen in observation group was significantly lower than that in control group(P<0.01).The HE staining results showed that the epidermal cell hyperplasia in observation group was apparent,and the elasticity of collagen fiber increased significantly compared with control group.Conclusions:The rhEGF transducted with nanometer crystalliter can effectively shorten the skin expansion time,reduce immediate retraction rate,and improve the skin quality and treatment effect and satisfaction of patients.