Application value of the joint detection of serum carcinoembryonic antigen and lysophosphatidic acid in patients with non-small cell lung cancer

Objective:To explore the application value of the joint detection of serum carcinoembryonic antigen(CEA) and lysophosphatidic acid(LPA) in patients with non-small cell lung cancer.Methods:Eighty-four patients with non-small cell lung cancer,84 patients with pneumonia and 84 healthy examined people were divided into the non-small cell lung cancer group,pneumonia group and healthy control group,respectively.The serum levels of CEA and LPA in three groups were detected,and the value of the joint examination of CEA and LPA in the diagnosis of non-small cell lung cancer was analyzed.Results:The levels of serum CEA and LPA in patients with non-small cell lung were significantly higher than those in pneumonia patients and healthy examined people(P<0.01).The positive rate of serum CEA in patients with adenocarcinoma(62.5%) was significantly higher than that in squamous cell carcinoma group and undifferentiated cancer group(P<0.05),and the differences of the LPA levels in non-small cell lung cancer group,pneumonia group and healthy control group were not statistically significant(P>0.05).The positive rates of CEA,LPA,and joint detection of CEA and PLA in the diagnosis of non-small cell lung cancer were 31.35%,30.16% and 38.89%,respectively.The accuracy rate,specificity and sensitivity of CEA detection were 67.86%,74.60% and 50.40%,respectively.The accuracy rate,specificity and sensitivity of LPA detection were 64.68%,72.62% and 42.86%,respectively.The accuracy rate,specificity and sensitivity of joint detection were 69.44%,70.24% and 60.71%,respectively.Conclusions:The joint detection of serum CEA and LPA can improve the diagnostic rate of non-small cell lung cancer,which is worthy of clinical application.