Effect of low molecular heparin combined with intermittent pneumatic pressure system in the prevention of deep venous thrombosis of lower extremities after laparoscopic radical cervical cancer surgery

Objective: To investigate the clinical significance of low molecular weight heparin(LMWH) combined with intermittent pneumatic pressure system(IPC) in the prevention of deep venous thrombosis(DVT) of lower extremities after laparoscopic radical cervical cancer surgery.Methods: One hundred and twenty-nine cervical cancer(FIGO ⅠB1-ⅡA1) patients were randomly divided into the control group(63 cases) and observation group(66 cases.The observation group were treated with IPC after 6h of operation,and LMWH after 24 h of operation.The control group were treated with general precautions.The operation time,peroperative bleeding,postoperative risk factors,and duration for bed rest between two groups were compared.Before and after operation,the levels of PLT,PT,APTT,D-D and FIB in two groups were measured,and the lower limbs vein were examined using ultrasound.Results: There was no statistical significance in operation time,blood loss,duration for bed rest,intraoperative blood transfusion and number of people with postoperative risk factors between two groups(P>0.05).The differences of the levels of PLT,PT,APTT,FIB and D-D between two groups before operation were not statistical significance(P>0.05).After 1 to 7 days of operation,the difference of the level of PLT between two groups was not statistical significance(P>0.05),and the levels of FIB and D-D in observation group were significantly lower than those in control group(P<0.01).After 1 to 5 days of operation,the levels of PT ad APTT in observation group were lower than those in control group(P<0.05 to P<0.01).The total incidence of thrombosis in observation group(1.52%) was lower than that in control group(11.11%)(P<0.05).Conclusions: LWMH combined with IPC can significantly prevent the incidence of DVT after laparoscopic radical cervical cancer.