Study on the correlations of ABI and IMT with severity of coronary lesions in premature coronary

Objective: To investigate the correlations of ankle brachial index(ABI) and intima-media thickness(IMT) with severity of coronary lesion in premature coronary artery disease(pCAD),and its early predictive value on pCAD.Methods: The ABI and carotid artery IMT in 136 pCAD patients detected by coronary angiography(CAG) were measured.The coronary score was calculated according to the degree of coronary stenosis,and the correlations of ABI and IMT with coronary score were analyzed.Results: The differences of the ABI and carotid artery IMT between single-and double-vessle lesion patients were not statistically significant(P>0.05),and the Gensini score in double-vessle lesion group was higher than that in single-vessle lesion group(P<0.05).The ABI and carotid artery IMT in three-vessle lesion group were significantly lower and higher than which in other groups,respectively(P<0.01),and the Gensini score in three-vessle lesion group was significantly higher than that in single and double-vessle lesion groups(P<0.05).The ABI value was negative correlation with the Gensini score of coronary artery(r=-0.523,P<0.01),and the carotid artery IMT was positive with correlation with the Gensini score of coronary artery(r=0.603,P<0.01).Conclusions: The ABI and carotid artery IMT have certain correlation with severity of coronary lesions in pCAD patients.The ABI significant decreasing and carotid artery IMT significant increasing can predict the severity of coronary lesion in pCAD patients.