Effect of inverse ratio ventilation on the airway pressure and perioperative PaCO₂ in gynecologic patients treated with laparoscopic surgery

Objective:To investigate the effects of inverse ratio ventilation(IRV) on the airway pressure and perioperative PaCO₂ in gynecologic patients treated with laparoscopic surgery.Methods:Sixty patients scheduled by laparoscopic resection for gynecologic tumor were randomly and double-blindly divided into the conventional ratio ventilation group(CRV group,I:E=1:2) and inverse ratio ventilation group(IRV group,I:E=2:1).The airway pressure and PaCO₂ value at different time points during perioperative period between two groups were compared.Results:The peak and plat pressure at 60 min after pneumoperitoneum in IRV group were lower than those in CRV group(P<0.05~P<0.01).There was no statistical significance in PaCO₂ value at all perioperative time points between two groups(P>0.05).Conclusions:IRV can effectively reduce the airway pressure in long-term pneumoperitoneum gynecological patients treated with laparoscopy,and has no effect on PaCO₂ during perioperative period.