The relationship between CYP2C19 gene polymorphisms and different types of acute coronary syndromes

ObjectiveTo investigate the relationship of CYP2C19 gene polymorphisms in cytochrome P450 oxidase(CYP450) and two types of acute coronary syndromes(ACS).

MethodsThe 12-lead ECG monitoring in 203 cases with ACS on admisssion were examined, and the myocardial enzyme indictors in all cases were examined on the second day after admission.The CYP2C19 genotypes of all patients were detected by PCR and gene sequencing technique.The coronary involvement in all patients were identified using coronary angiography(CAG).

ResultsThe difference of the CYP2C19 gene polymorphisms between ST-segment elevation ACS group and non-ST-segment elevation ACS group was not statistically significant(P>0.05), and the differences of the levels of blood glucose, C-reactive protein(CRP) and serum homocysteine, and prevalence rate of hypertension between two groups were statistically significant(P < 0.05 to P < 0.01).The results of logistic regression analysis showed that there was no statistical significance in CYP2C19 gene polymorphisms between two groups(OR=0.71, P>0.05), and the differences of the levels of blood glucose, CRP, HCY and HDL-C and prevalence rate of hypertension between two groups were statistically significant(P < 0.05).

ConclusionsThere is no association between CYP2C19 polymorphism and different types of ACS, and the levels of blood glucose, HCY and CRP, and HDL-C level in patients with ST-segment elevation ACS may be higher and lower, respectively.