Study on the influencing factor of early renal damage in patients with primary hypertension

ObjectiveTo study the risk factors of early renal damage in patients with primary hypertension.

MethodsOne hundred and eighty-seven patients with primary hypertension were divided into the hypertension group(116 cases) and hypertensive renal damage group(71 cases) according to the urine albumin/creatinine ratio(UACR), the clinical data, 24 h systolic blood pressure(SBP) and diastolic blood pressure(DBP) between two groups were compared, and the risk factors of early renal damage in patients with primary hypertension were analyzed.

ResultsThe differences of gender, age, body mass index, smoking and drinking between two groups were not statistically significant(P>0.05), the disease duration in hypertension group was significantly shorter than that in hypertensive renal damage group(P < 0.01), and the differences of dSBP, dDBP, 24hSSD, 24hDSD, dSSD and dDSD between two groups were statistically significant(P < 0.05 to P < 0.01).The UACR was set as the dependent variable, the disease duration, dSBP, dDBP, 24hSSD, 24hDSD, dSSD and dDSD were set as the independent variable, and the multiple logistic regression analysis showed that the disease duration, dSBP, 24hSSD, 24hDSD, dSSD and dDSD were the independent influencing factors of UACR(P < 0.01).

ConclusionsThe disease duration, dSBP, 24hSSD, 24hDSD, dSSD and dDSD are the independent risk factors of renal function damage in patients with primary hypertension.