Bioinformatics analysis of the differential expression of miRNA-181b in peripheral blood of schizophrenic patients

ObjectiveTo analyze the target gene, transcription factor and signal pathway of the differential expression of miRNA-181b in the peripheral blood of schizophrenic patients.

MethodsThe miRNA-181b target gene was analyzed using the DIANA-TarBase database, the GO function and KEGG pathway enrichment of miRNA-181b gene were analyzed using DIANA-miPath V.3 software, and the transcription factors of miRNA-181b were analyzed using the DIANA-miRGen v3.0 database.

ResultsThere were 1 344 target genes of miRNA-181b, and the target genes ARHGAP11A, PPA1, YY1 and ZC3H12B significantly expressed.The target genes of miRNA-181b were widely involved in the regulation of biological processes(including molecular function, RNA binding and cell composition).The results of KEGG bioinformatics analysis showed that the target gene of miRNA-181b enriched 12 signal pathways, which included the hippo signal pathway, p53 signal pathway, HIF-1 signal pathway and lysine degradation.Seven transcription factors were significantly associated with miRNA-181b, and JUN, EGR1 and MEF2C were significantly associated with schizophrenia.

ConclusionsThe multiple target genes, signal pathways and transcription factors are closely related to the onset of schizophrenia using the bioinformatics analysis of the differential expression of miRNA-181b in the peripheral blood of schizophrenic patients.