Effect of continued vacuum sealing drainage on nerve conduction and oxidative stress in diabetic foot patients

ObjectiveTo explore the effects of continued vacuum sealing drainage on nerve conduction and oxidative stress in diabetic foot patients.

MethodsSeventy patients with diabetic foot were randomly divided into the control group and observation group(35 cases each group).The control group was treated with conventional method combined with defibrase,and the observation group was treated with continued vacuum sealing drainage based on the conventional treatment.The total effective rate,adverse reaction rate,motor nerve conduction velocity(MCV),sensory nerve conduction velocity(SCV),artery blood flow velocity,antioxidant superoxide anion free radical(Anti-O^2-)activity,activity of superoxide dismutase(SOD),nitric oxide(NO)content,level of malondialdehyde(MDA),total content of nitric oxide synthase(TNOS) and inducible nitric oxide synthase(iNOS) level between two groups were compared before and after treatment.

ResultsThe clinical total effective rate in observation group(94.29%) was significantly higher than that in control group(77.14%)(P<0.05).The MCV and SCV in two groups increased(P<0.05 to P<0.01),and which in observation group was higher than that in control group(P<0.05).After treatment,the plasma levels of iNOS and MDA increased(P<0.05 to P<0.01),the levels of SOD,Anti-O^2-,NO and TNOS decreased(P<0.05 to P<0.01),and the differences of the increasing and decreasing degrees of those between two groups were not statistically significant(P>0.05).After treatment,the blood flow velocity in observation group was higher than that in control group(P<0.01).The incidence rates of adverse reaction in observation group and control group were 14.29% and 8.57%,respectively,and the difference of which was not statistically significant(P>0.05).

ConclusionsContinued vacuum sealing drainage in the treatment of diabetic foot patients can improve the nerve conduction velocity,promote the healing of foot ulcers,and do not significantly aggravate the oxidative stress reaction of patients,which is worthy of clinical application.