Study on the risk factors of early-onset coronary heart disease in female

ObjectiveTo study the risk factors of early-onset coronary heart disease in female and characteristics of coronary artery lesion.

MethodsA total of 66 women(age of onset ≤ 65 years) with early-onset coronary heart disease diagnosed by coronary angiography, 42 healthy women, and 70 late-onset coronary heart disease women(age of onset > 65 years) from June 2015 to June 2018 were divided into the early-onset group, control group and late-onset group, respectively.The general information, disease history, and biochemical indicators among three groups were compared.

ResultsThe positive rate of smoking history and hypertension history in early-onset group(21.2% and 45.5%) were higher than those in control group(4.8% and 9.5%) and late-onset group(11.4% and 35.7%)(P < 0.05 to P < 0.01).The levels of urea nitrogen, total cholesterol, low density lipoprotein, lipoprotein, triglyceride, lactate dehydrogenase and creatine kinase in early-onset group were significantly higher than those in the healthy control group(P < 0.05 to P < 0.01).Compared with the late-onset group, the level of creatinine was lower(P < 0.01), while the levels of urea nitrogen, lipoprotein, low-density lipoprotein, lactate dehydrogenase and creatine kinase were higher in arly-onset group(P < 0.05 to P < 0.01).

ConclusionsThe smoking, hypertension history, and abnormal levels of blood urea nitrogen, lipoprotein, low density lipoprotein, lactate dehydrogenase and creatine kinase may be the risk factors for early-onset of coronary heart disease in women.The abnormal increasing of total cholesterol and triglyceride levels may be the risk factors of coronary heart disease in middle-aged and young women.