Study on the correlation between cystatin C, and hypertensive intracerebral hemorrhage and carotid atherosclerotic plaque

ObjectiveTo investigate the correlation between cystatin C, (Cys C)and hypertensive intracerebral hemorrhage and carotid atherosclerotic plaque.

MethodsOne hundred and fifteen patients with hypertensive cerebral hemorrhage were set as the observation group, and 71 healthy examination people were as the control group.The general information and laboratory inspection between two groups were compared, and the risk factors of cerebral hemorrhage were analyzed using multivariate logistic regression.The observation group was subdivided into the plaque group(57 cases) and nonplaque group(58 cases) according the results of carotid artery ultrasonography, the general information and laboratory inspection between two subgroups were compared, and the risk factors of plaque formation were analyzed using multivariate logistic regression.

ResultsThe levels of serum Cys C and C-reactive protein(CRP) in observation group were significantly higher than those in control group(P < 0.01), and the level of high-density lipoprotein in observation group was significantly lower than that in control group(P < 0.01).Multivariate logistic regression analysis showed that the Cys C and level were the independent risk factors of cerebral hemorrhage.The age, incidence rate of hyperlipidemia and Cys C level in plaque group were significantly higher than those in nonplaque group(P < 0.05 to P < 0.01).Multivariate logistic regression analysis showed that the age and Cys C were the independent risk factors of plaque formation in cerebral hemorrhage patients.

ConclusionsThe serum level of Cys C is closely related to the hypertensive intracerebral hemorrhage and carotid plaque formation, and the early detection of serum Cys C level has certain guiding significance in evaluating the hypertensive intracerebral hemorrhage and carotid plaque.