Value of the serum albumin, cholinesterase and prothrombin activity in the diagnosis of viral hepatitis cirrhosis

ObjectiveTo investigate the value of serum albumin (ALB), cholinesterase (CHE) and prothrombin activity (PTA) in the diagnosis of viral hepatitis cirrhosis.

MethodsSixty-three viral hepatitis cirrhosis patients, 60 viral hepatitis patients and 60 healthy volunteers were divided into the cirrhosis group, hepatitis group and control group, respectively.The levels of ALB, CHE and PTA were detected in three groups.

ResultsThe levels of ALB, CHE and PTA in cirrhosis group were significantly lower than those in hepatitis group and control group (P < 0.01).The levels of ALB, CHE and PTA in Child-pugh C patients were significantly lower than those in Child-pugh B and A in cirrhosis group (P < 0.05 to P < 0.01).The areas under the ROC curve of ALB, CHE and PTA in diagnosing viral hepatitis cirrhosis were 0.835, 0.897 and 0.746, respectively; the cut-off values of those were 31.41g/L, 3 785.41 U/L and 36.59%, respectively; the sensitivity of those were 73.30%, 85.00% and 93.30%, respectively, and the specificities of whose were 81.00%, 79.40% and 44.44%, respectively.

ConclusionsThe levels of ALB, CHE and PTA in patients with viral hepatitis cirrhosis significantly decrease, which can reflect the classification of Child-pugh, and has certain diagnostic value.