Application value of event-related potential P300 in nerve disease complicated with cognitive impairment

ObjectiveTo evaluate the sensitivity and superiority of P300 combined with MMSE and MoCA in the evaluation of the cognitive function in neuropathy patients complicated with cognitive impairment.

MethodsP300 was measured in 33 patients with organic diseases (such as cerebral infarction, hypertension and Parkinson's disease) and 21 healthy people, and the cognitive function in all cases was evaluated using MMSE and MoCA.The latency and amplitude of P300 between patients and healthy people were compared.The correlation of psychological scale score with latency and amplitude of P300 between patients and healthy people were compared.

ResultsThe scores of MMSE and MoCA in control group were higher than those in observation group (P < 0.05 and P < 0.01), the latency of P300 in control group was significantly lower than that in observation group (P < 0.01), and the difference of the amplitude between two groups was not statistically significant (P>0.05).The latency of P300 was negatively correlated with MMSE and MoCA scores (P < 0.05).The amplitude of P300 was positively correlated with MMSE score (P < 0.05), and not correlated with MoCA score (P>0.05).

ConclusionsP300 can be used as a biological indicator in evaluating organic disease complicated with cognitive impairment.P300 combined with MoCA scale can more sensitively detect the early cognitive impairment of patients, which is worthy of further clinical application.