ObjectiveTo study the correlations between the partial pressure of carbon dioxide (PCO2) and levels of fibrinogen (FIB), D-dimmer in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
MethodsExcluding the possible coexisting disease and related factors affecting the coagulation indexes, the correlations between PCO2 and levels of FIB, D-dimmer in 92 patients with AECOPD were analyzed.
ResultsThe levels of FIB and D-dimmer of AECOPD patients in PCO2 increasing group were significantly higher than those in normal PCO2 group (P < 0.01).The levels of FIB and D-dimmer were positively correlated with the PCO2 (r=0.686, 0.741, P < 0.05).
ConclusionsThe more serious the carbon dioxide retention is, the higher the incidence of coagulation dysfunction is in AECOPD patients.