Clinical significance of the serum level change of 8-hydroxy-2'-deoxyguanosine in patients with varicocele

ObjectiveTo investigate the clinical value of the serum level change of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in varicocele (VC) patients.

MethodsThe serum levels of 8-OHdG in 30 VC patients treated with high spermatic vein ligation were measured before and after 3 months of surgery.The differences of the serum levels of 8-OHdG between before and after surgery were compared, and the correlations of the level of 8-OHdG with incidence rate of single or bilateral VC and width of spermatic vein were analyzed.

ResultsBefore surgery, there was no statistically significant in the serum level of 8-OHdG between the VC unilateral group and bilateral group (P>0.05), and there was no statistical significance in the serum levels of 8-OHdG level among patients with different widths of spermatic vein (P>0.05).The postoperative 8-OHdG level(261.64±82.55) pg/mL was significantly lower than that of preoperative level(327.20±101.86) pg/mL in 30 patients (P < 0.01).

ConclusionsThe serum level of 8-OHdG increasing, an indicator of oxidative stress, is related to the infertility caused by VC, and the level of 8-OHdG decreasing has a certain clinical significance in judging the prognosis of VC patients treated with operation.