Study on the relationship between the serum level of macrophage inflammatory protein-1α and disease severity in patients with traumatic brain injury

ObjectiveTo investigate the relationship between the serum level of macrophage inflammatory protein-1α (MIP) -1α and disease severity in patients with traumatic brain injury.

MethodsNinety-eight patients with traumatic brain injury were set as the observation group, and subdivided into the high MIP-1α group and low MIP-1α group according to the median of MIP-1α (49 cases each group).Fifty healthy people were set as the control group.At the same time, the coma degree in observation group was assessed using Glasgow Coma Scale (GCS), and the serum nerve injury indices and content of excitatory amino acid were determined.

ResultsOn admission, the serum content of MIP-1α in observation group(92.16±9.85) pg/mL was significantly higher than that in control group(74.51±8.68) pg/mL (P < 0.01).The GCS score in high MIP-1α group (7.27±0.91) was significantly lower than that in low MIP-1α group (11.09±1.82) (P < 0.01).On admission, the serum neural damage indices, such as glial fibrillary acidic protein, neuron-specific enolase and S100B, and the serum contents of excitatory amino acid glutamic acid and aspartic acid in high MIP-1α group were significantly higher than those in low MIP-1α group (P < 0.01).

ConclusionsThe serum content of MIP-1α in patients with traumatic brain injury increases, and the specific content is positively correlated with the severity of brain injury.