Analysis of the nosocomial infection status and its risk factors in very-low-birth-weight infants

ObjectiveTo investigate the nosocomial infection status of very-low-birth-weight infants (VLBWI) in the neonatal intensive care unit in a maternal and child health care hospital in Shanghai, and analyze the nosocomial infection status of VLBWI and its risk factors.

MethodsAccording to the retrospective cohort study, the medical histories of all VLBWI with hospitalization time more than 48 hours from 2011 to 2015 were collected.Based on the medical record management system, all data of patients with nosocomial infection were identified according to the nosocomial infection report, and were analyzed using SPSS24.0 software.

ResultsThe infection rate in VLBWI was 44.3%.The main infection sites were lower respiratory tract (14.2%) and blood (11.6%), the difference of the composition ratio of nosocomial infection site was statistically significant in each year (P < 0.01), and the gram-negative bacterium was the mainly pathogenic bacterium (72.4%).Multivariate logistic regression analysis showed that the multiple births, long duration of mechanical ventilation, intravenous nutrition and hospitalization, and mother with premature rupture of membrane history were the independent risk factors of nosocomial infection in VLBWI (P < 0.01).

ConclusionsStrengthening perinatal health care and timely intervening the premature infants with high risk factors should be implemented.