Analysis of the correlation of serum liver transaminase with metabolic syndrome of health examinees in a hospital

ObjectiveTo understand the relationship between the serum level of liver transaminase and risk of metabolic syndrome.

MethodsThe data of physical examination and laboratory examination from 2 460 health examineesincluding 1 457 males and 1 003 females, an average age for (46.64±14.81) years in a hospital were investigated.The levels of AST, ALT and ratio of AST to ALT were divided into four groups (Q1, Q2, Q3 and Q4) by quartile method.The relationship between the serum level of liver transaminase and metabolic syndrome was analyzed using the Spearman correlation analysis and logistic regression model, and the data were processed using SPSS 21.0 software.

ResultsThe crude prevalence of metabolic syndrome was 17.03%, which in male was higher than that in female (χ²=48.542, P < 0.05).The levels of AST and ALT were positively correlated with the abnormal number of metabolic components, but the ratio of AST to ALT was negatively correlated with the abnormal number of metabolic components.By adjusting the variates of age, smoking and alcohol, compared with Q1 group, the metabolic syndrome risk of ALT level in Q4 group were 4.96 times in males (95%CI:3.33 to 7.38), and 2.64 times in females (95%CI:1.29 to 5.43), and the metabolic syndrome risk of AST level in Q4 group was 2.22 times in males (95%CI:1.55 to 3.18).

ConclusionsSerum liver transaminase is closely related to the components of metabolic syndrome.The increasing levels of AST and ALT may enhance the risk of metabolic syndrome.