Correlation between the plasma level of D-dimer, and chemotherapeutic effect and prognosis in patients with advanced esophageal squamous cell carcinoma

ObjectiveTo investigate the application value of the plasma D-dimer level in the first-line palliative chemotherapy of the advanced esophageal squamous cell carcinoma.

MethodsNinety-one patients with advanced esophageal carcinoma were divided into the normal group(plasma D-dimer level ≤ 0.5 μg/mL) and increasing group(plasma D-dimer level >0.5 μg/mL) according to the plasma D-dimer level before the first-line palliative chemotherapy.The correlations between the plasma D-dimer level, and clinical features, therapeutic effects and prognosis of patients were analyzed.

ResultsThe plasma D-dimer level was correlated with the platelet and fibrinogen levels of patients.The disease control rate in increasing group(33.33%) was lower than that in normal group(69.23%)(P < 0.05).The results of COX multivariate analysis showed that the plasma level of D-dimer was an independent predictive factor of prognosis(P < 0.01).

ConclusionsThe plasma level of D-dimer may be a potential biomarker of the efficacy of the first-line palliative chemotherapy, which can provide certain basis in evaluating prognosis.