Application value of intravenous nitroglycerin controlled hypotension in the gastroscopy of high risk population with hypertension

ObjectiveTo investigate the application value of intravenous nitroglycerin controlled hypotension in the gastroscopy of high risk population with hypertension, and compare the effects between nitroglycerin and nifedipine by oral in controlling blood pressure.

MethodsOne hundred and twenty hypertensive patients treated with electronic gastroscopy were randomly divided into the group A(treatment with nifedipine by oral), group B(treatment with nitroglycerin by oral), and group C(treatment with intravenous nitroglycerin).Forty healthy people were set as control group.The blood pressure, heart rate, ECG and incidence rate of adverse reactions in four groups were observed through the whole process of gastroscopy inspection.

ResultsBefore inspection, the levels of systolic blood pressure and heart rate in group A and group B were higher than those in control group(P < 0.05 to P < 0.01).During the inspection, the levels of systolic and diastole pressure in group A and group B, and heart rate in group A were higher than those in group C and control group(P < 0.05 to P < 0.01).After inspection, the level of systolic pressure and heart rate in group A were higher than those in group C and control group(P < 0.05 to P < 0.01).The level of systolic pressure before inspection and heart rate after inspection in group C were higher than those in control group(P < 0.01 and P < 0.05), and the differences of other indexes between group C and control group were not statistically significant(P>0.05).Before and after inspection, the differences of the incidence rates of sinus tachycardia, ST change, ectopic heart rhythm and conduction block among three groups were not statistically significant(P>0.05).During the inspection, the differences of ST change and ectopic heart rhythm among three groups were statistically significant(P < 0.05).The differences of the incidence rates of adverse reactions among four groups were not statistically significant(P>0.05).

ConclusionsIntravenous nitroglycerin is a safe method in controlling the blood pressure during gastroscopy, the effect of which is better than that of nifedipine and nitroglycerin by oral.