Comparison of the safety and efficacy of different dosages of etomidate combined with propofol in colonoscopy of elderly patients

ObjectiveTo compare the safety and efficacy of different dosages of etomidate combined with propofol in colonoscopy of elderly patients.

MethodsOne hundred and eighty patients scheduled by colonoscopy, were randomly divided into the propofol group(group P), propofol combined with etomidate group(group PE) and etomidate combined with propofol group(group EP).All patients were intravenously injected with 1 μg/kg fentanyl before 1 min of colonoscopy.The group P, group PE and group EP were injected with 1.5 mg/kg propofol, 1.0 mg/kg propofol combined with 0.05 mg/kg etomidate and 0.75 mg/kg propofol combined with 0.075 mg/kg etomidate, respectively.The mean aterial blood pressure, heart rate, saturation of peripheral oxygen, anesthesia duration, operation time, recovery time, discharge time, adverse reaction, and satisfaction degrees of patients, endoscopists and anesthetists in three groups were evaluated.

ResultsCompared with the group P and group PE, the recovery time and discharge time in the group EP were significantly longer(P < 0.05 to P < 0.01).The incidence rates of hypotension, bradycardia and hypoxemia in the group P were significantly higher compared with the group PE and group EP(P < 0.05 to P < 0.01).The satisfaction degrees on anesthetists in the group PE and group EP were higher compared with the group P(P < 0.01).

ConclusionsThe recovery time and discharge time in patients induced by 1.0 mg/kg propofol combined with 0.05 mg/kg etomida are shorter, and adverse reaction is less.