Investigation of the influence of Helicobacter pylori infection on the levels of homocysteine and blood lipid

ObjectiveTo explore the influence of Helicobacter pylori(HP) infection on the levels of homocysteine(Hcy) and blood lipid.

MethodsOne hundred and two hospitalized patients were divided into the HP infection group and HP uninfection group according to the HP infection situation, respectively.The levels of Hcy, total cholesterol(TC), triglyceride(TG), high-density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterol(LDL-C), were detected in two groups.The influence of HP infection on the levels of Hcy and blood lipid between two groups was compared, and the correlation between the level of Hcy and blood lipid was analyzed in two groups.

ResultsThe detection rates of HHcy in HP infection group and HP uninfection group were 19.61%(10/51) and 5.88%(3/51), respectively, and the difference of which was statistically significant(P < 0.05).The abnormal detection rates of the levels of TC, HDL-C and LDL-C in HP infection group were higher than those in HP uninfection group(P < 0.05 to P < 0.01).The levels of TC and TG in HP infection group were higher compared with the HP uninfection group, and the difference of which was not statistically significant(P>0.05).The levels of Hcy and LDL-C in HP infection group were higher than those in HP uninfection group(P < 0.05).The level of HDL-C in HP infection group was lower than that in HP uninfection group(P < 0.05).HP antibody level was positively correlated with the levels of Hcy, TC and LDL-C(P < 0.05).

ConclusionsHP infection is closely related to the occurrence of HHcy, and the abnormal level of blood lipid, can lead to the risk increasing of cardiovascular disease.