Clinical effect of prostaglandins combined with oxytocin in the prevention of high risk pregnancy and postpartum hemorrhage after cesarean section

ObjectiveTo investigate the preventive effects of carboprost tromethamine or carboprost methylate combined with oxytocin on postpartum hemorrhage in high risk pregnant women treated with cesarean section.

MethodsOne hundred and eighty high risk pregnant women treated with cesarean section were randomly divided into group A and group B(90 cases each group).Group A was intravenously injected with 10 U oxytocin combined with intramuscular injection 250 μg carboprost tromethamine, and group B was intravenously injected with 10 U oxytocin combined with 1 mg carboprost methylate by sublingual administration after delivery.The amount of bleeding, and rates of postpartum hemorrhage, blood transfusion, intervention of additional hemostasis and occurrence of adverse reaction were compared between two groups.

ResultsThe intraoperative, postoperative 2 h and postoperative 24 h haemorrhage amount in group A were significantly less than those in group B(P < 0.05 to P < 0.01).The differences of the incidence of postpartum hemorrhage, and rates of blood transfusion and intervention of additional hemostatic measures between two groups were not statistically significnat(P>0.05).The average amount of postpartum bleeding in 12 cases of group A and 17 cases of group B were(841.34±232.56)mL and(857.62±227.37)mL, respectively, and the difference of which was not statistically significant(P>0.05).The difference of the incidence rate of adverse reaction between two gorups was not statistically significant(P>0.05).

ConclusionsCarboprost tromethamine or carboprost methylate combined with oxytocin in treating postpartum hemorrhage in high-risk pregnant treated with cesarean section has good preventive effect and less side effects.Carboprost tromethamine has a certain advantage in reducing the amount of bleeding.