Analysis of the related factors of affecting HSP recurrence and HSP-related renal insufficiency in children

ObjectiveTo analyze the related factors of affecting Henoch-Schonlein purpura(HSP) recurrence and HSP-related renal insufficiency in children.

MethodsOne hundred and twenty-two children with HSP were divided into group A(38 cases with HSP recurrence) and group B(84 cases without HSP recurrence).According to the results of urine routine examination, the HSP-related renal insufficiency in 41 cases and HSP-unrelated renal insufficiency in 81 cases were divided into the group Ⅰ and group Ⅱ, respectively.The influencing factors of HSP recurrence and HSP-related renal insufficiency in HSP children were analyzed using univariate and multivariate logistic regression method.

ResultsThe proportions of unprophylaxis, history of respiratory tract infection, uncontrolled diet, eosinophil(EOS) increasing and unrestricted exercise in group A were significantly higher than those in group B(P < 0.05 to P < 0.01).The proportions of age>10 years old, platelet(PLT) count increasing, white blood cell(WBC) increasing, repeated eruption of rash, abnormal urinary microalbuminuria and total immunoglobulin(IgE) increasing in group Ⅰ were higher than those in group Ⅱ(P < 0.05).The results of multivariate logistic regression analysis showed that the unprophylaxis, history of respiratory tract infection, uncontrolled diet and EOS increasing were the influencing factors of the HSP recurrence(P < 0.05 to P < 0.01), and the age >10 years old, PLT increasing, WBC increasing, repeated eruption of rash, abnormal urinary microalbuminuria and IgE increasing were the influencing factors of HSP-related renal insufficiency in children(P < 0.05 to P < 0.01).

ConclusionsThe influencing factors of the HSP recurrence include the unprophylaxis, history of respiratory tract infection, uncontrolled diet and EOS increasing, and the influencing factors of HSP-related renal insufficiency include the age, PLT, WBC, urinary microalbuminuria and IgE.The above factors should be paid attention to, closely observed and timely intervened to avoid HSP recurrence or HSP-related renal insufficiency.