Analysis of the effects of the co-induction of midazolam, fentanyl and propofol on hemodynamics using weighted modification method

ObjectiveTo investigate the effects of the co-induction of midazolam(Mid), fentanyl(Fen) and propofol(Pro) on hemodynamics using weighted modification method.

MethodsSixty patients with ASA class Ⅰ or Ⅱ scheduled by laparoscopic operation were evenly distributed to 6 different dose groups according to the weighted modification method.The anesthesia induction was performed by injecting Mid(15 s), Fen(15 s), Pro(30 s) and 0.6 mg/kg of rocuronium bromide successively.Endotracheal intubation was performed after 3 min of Pro injection.The MAP and HR were recorded before induction, after 1 and 2 min of induction, at intubation, after 1, 3, 5 and 7 min of intubation.

ResultsThe mean arterial pressure was used as the evaluation index, the importance of the three drugs in the formulation was Pro > Mid > Fen, and the theoretical optimization of Pro, Mid and Fen were 1.5 mg/kg, 0.06 mg/kg and 0.005 mg/kg, respectively.The HR was used as the evaluation index, the importance of the three drugs in the formulation was Fen > Pro > Mid, and the theoretical optimization of Mid, Fen and Pro were 0.06 mg/kg, 0.005 mg/kg and 1.5 mg/kg, respectively.

ConclusionsPro and Fen play a major role in maintaining hemodynamic stability, Mid, Pro and Fen have synergistic effects, and the ideal induced doses of Mid, Fen and Pro are 0.06 mg/kg, 0.005 mg/kg and 1.25 mg/kg, respectively.