Clinical value of thrombelastography in predicting the lacunar stroke developing into progressive lacunar stroke

ObjectiveTo investigate the clinical value of thrombelastography(TEG) in predicting the lacunar stroke(LS) developing into progressive lacunar stroke(PLS).

MethodsOne hundred and forty-two LS patients were divided into the PLS group(46 cases) and Non-PLS group(96 cases).The maximum amplitude, clotting angle, clotting time and reaction time of TEG parameters in two groups were detected using TEG5000 analyzer.

ResultsThe maximum amplitude and clotting angle in PLS group were significantly larger than those in Non-PLS group(P < 0.01), and the clotting time and reaction time in PLS group were significantly shorter than those in Non-PLS group(P < 0.01).The results of Pearson linear correlation analysis showed the maximum amplitude and clotting angle were positively correlated with NHISS score of PLS patients(P < 0.05), and the clotting time and reaction time were negatively correlated with NHISS score of PLS patients(P < 0.01).The logistic regression analysis showed that the maximum amplitude and clotting angle could be used as the independent risk factors of the LS developing into PLS, and the clotting time and reaction time could be used as independent protective factors of the LS developing into PLS(P < 0.05 to P < 0.01).

ConclusionsThe value of TEG in the prediction of the LS developing into PLS is obvious.The larger the maximum amplitude and clotting angle are, and the shorter the clotting time and reaction time are, the higher the risk of the LS developing into PLS is.